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Investigation of Bioactive Constituents and the Antitumour principle from Butea monosperma
- The ethanol extract of the flower of Butea monosperma (Fabaceae) was found to contain butein (1), butin (2), monospermoside (3), medicarpin-3-O-glucoside (4), ß-sitosterol glucoside (5), sulphurein (6), isomonospermoside (7), isocoreopsin (8), butrin (9), isobutrin (10) ergost-5-en-3ß-ol (11), stigmasterol (12), ß-sitosterol (13), 6,10,14-trimethyl-2-pentadecanone (14), methyl hexadecanoate(15), methyl octadecanoate (16), and heptacosane (17), whose structures were determined by modern spectroscopic techniques. In which, medicarpin-3-O-glucoside (4) was isolated for the first time from this plant. The antitumour activity of three pure compounds (1), (9) and (10) were tested by using 6 human tumour cell lines. Compound (1) which showed activity in the primary screening was further screened by 36 human tumour cell lines. Compound (1) showed mean IC70 value at 11.34 µg/mL and mean IC50 value at 7.39 µg/mL in the ovarian tumour cell line.
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