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Novel anticancer agents, kayeassamins C I from the flower of Kayea assamica of Myanmar
- A CHCl3-soluble fraction of 70% EtOH extract of the flower of Kayea assamica from Myanmar exhibited 100% preferential cytotoxicity (PC100) against human pancreatic cancer PANC-1 cells under nutrient-deprived conditions at 1 lg/mL. Bioassay-guided fractionation and isolation afforded nine new coumarins, kayeassamins A (8), B (9), and CI (17), together with nine known coumarins (1018). The structures of these compounds were identified by extensive spectroscopic techniques as well as by comparison with published data. Absolute configuration at C-10 of 1 was established as S-configuration by the modifiedMosher method. All the isolates were evaluated for their in vitro preferential cytotoxicity using novel anti-austerity strategy. Among them, the novel coumarins, kayeassamins A (8), B (9), D (2), E (3), and G (5) exhibited the most potent preferential cytotoxicity (PC100 1 lM) in a concentration- and time- dependent manner and induced apoptosis-like morphological changes of PANC-1 cells within 24 h of treatment. Based on the observed cytotoxicity, structure-activity relationships have been established.
Nwet Nwet Win