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Novel anticancer agents, kayeassamins A and B from the flower of Kayea assamica of Myanmar
- The CHCl3-soluble fraction of 70% EtOH extract of the flower of Kayea assamica completely killed human pancreatic PANC-1 cancer cells preferentially under nutrient-deprived conditions at 1 lg/mL. Bioassayguided fractionation and isolation afforded two novel compounds, kayeassamins A (1) and B (2). Their structures were elucidated using extensive spectroscopic methods and the modified Mosher method. Each compound showed 100% preferential cytotoxicity (PC100) against PANC-1 cells under nutrientdeprived conditions at 1 lM. Furthermore, both compounds inhibited the migration of PANC-1 cells in the wound closure assay.
Nwet Nwet Win