Show simple item record

Please use this identifier to cite or link to this item: http://uyr.uy.edu.mm/handle/123456789/125
dc.contributor.authorNwet Nwet Win
dc.contributor.authorAwale, Suresh
dc.contributor.authorEsumi, Hiroyasu
dc.contributor.authorTezuka, Yasuhiro
dc.contributor.authorKadota, Shigetoshi
dc.date.accessioned2016-11-07T19:00:38Z
dc.date.available2016-11-07T19:00:38Z
dc.date.issued2007
dc.identifier.urihttp://uyr.uy.edu.mm/handle/123456789/125
dc.descriptionJ. Nat. Prod. 2007, 70, 1582–1587
dc.description.abstractThe chloroform extract of rhizomes of Boesenbergia pandurata demonstrated marked preferential cytotoxicity against human pancreatic PANC-1 cancer cells in nutrient-deprived medium. Bioactivity-directed investigation of this extract yielded four new secondary metabolites, geranyl-2,4-dihydroxy-6-phenethylbenzoate (1), 2′,4′-dihydroxy-3′-(1′′-geranyl)- 6′-methoxychalcone (2), (1′R,2′S,6′R)-2-hydroxyisopanduratin A (3), and (2R)-8-geranylpinostrobin (4), and twenty known compounds (5–24). Among the known compounds, (2S)-6-geranylpinostrobin (5), (()-6-methoxypanduratin A (6), and (2S)-7,8-dihydro-5-hydroxy-2-methyl-2-(4′′-methyl-3′′-pentenyl)-8-phenyl-2H,6H-benzo[1,2-b:5,4-b′]dipyran-6-one (7) were isolated for the first time from a natural source. The structures of these compounds were elucidated using extensive spectroscopic techniques including CD measurements. All the isolated compounds showed varying degrees of in Vitro preferential cytotoxicity against PANC-1 cells. Nicolaioidesin B (11) and panduratin A (17) were most potent, each showing a PC100 at 2.5 µM.
dc.titleBioactive Secondary Metabolites from Boesenbergia pandurata of Myanmar and Their Preferential Cytotoxicity against Human Pancreatic Cancer PANC-1 Cell Line in Nutrient-Deprived Mediumlanguage
dc.typearticle


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record