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    Please use this identifier to cite or link to this item: http://uyr.uy.edu.mm/handle/123456789/128

    A new polyoxygenated cyclohexene and a new megastigmane glycoside from Uvaria grandiflora

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    Abstract
    • A new polyoxygenated cyclohexene, (-)-3-O-debenzoylzeylenone (1), and a new megastigmane glycoside, grandionoside A (2), were isolated from the aerial parts of Uvaria grandiflora collected in Vietnam, together with ten known compounds including polyoxygenated cyclohexenes (3-6), a triterpenoid (7), an alkaloid (8), a long chain alcohol (9), hexenyl glycopyranoside (10), and saponins (11-12). Their chemical structures were elucidated by a combination of extensive NMR spectroscopy with X-ray crystallographic analysis for 1, and chemical conversion for 2. Compound 1 exhibited significant cytotoxicity against the LU-1 and SK-Mel-2 cell lines with IC50 values of 4.68 and 3.63 μM, respectively. Remarkably, the cytotoxicity of 12 against the LU-1, KB, Hep-G2, MKN-7, and SW-480 cell lines was comparable to that of ellipticine, the positive control, with IC50 values ranging from 1.24 to 1.60 μM.
    Collections
    • Department of Chemistry Collection
    Date
    • 2015
    Author
    • Ho, Duc Viet
    • Kodama, Takeshi
    • Le, Hien Thi Bich
    • Phan, Kiem Van
    • Do, Thao Thi
    • Bui, Tai Huu
    • Le, Anh Tuan
    • Nwet Nwet Win
    • Imagawa, Hiroshi
    • Ito, Takuya
    • Morita, Hiroyuki
    • Nguyen, Hoai Thi
    Type
    • article
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