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Isolation of Active Organic Compounds from Phyllanthus Aibizzoides (Kurz Hook.f.) (Shit-Shar) and Phyllanthus Maderaspatensis L. (Taw-Zee-Phyu)
- This research deals with the investigation of active organic compounds from the whole plant of Taw-zee-phyu, TZP (Phyllanthus maderaspatensis L.) and barks of Shit-shar, SS (Phyllanthus albizzioides (Kurz) Hook.f.). One compound, quercetin-3-O-β-D- glucopyranosyl (1-4) α-rhamnopyranoside from EtOAc extract of TZP and two compounds : lupeol and (E)-pentyl 3-3,4dihydroxyphenyl acrylate from pet-ether extract of SS bark were isolated by solvent extraction followed by column and thin layer chromatographic separation methods. The structures of isolated compounds were elucidated and identified by modern spectroscopic techniques such as UV, FT IR, 1H NMR, 13C NMR, 2DNMR such as 1H-1H COSY, NOESY, HSQC and HMBC, and ESI- MS.All of these isolated compounds showed the antioxidant activity in the order of : quercetin-3-O-β-D- glucopyranosyl (1-4) α- rhamnopyranoside (IC50= 2.50 μg/mL) > lupeol (IC50 = 4.97 μg/mL) > (E)-pentyl 3-3,4dihydroxyphenyl acrylate (IC50 = 7.78 μg/mL), determined by DPPH radical scavenging assay.
Myint Myint Khin
Khin Chaw Win
Myat Noe Hlaing
- University of Yangon Research Journal