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Biological Activities of Peltophorum pterocarpum of Myanmar and Isolation of Secondary Metabolites from its Flowers
- ) The isolation of petroleum ether and ethyl acetate crude extracts of Peltophorum pterocarpum afforded physcion (1), β-sitosterol (2), naringenin (3), gallic acid (4), bergenin (5) and 11-O-acetylbergenin (6). The isolated compounds 1-6 were identified using UV, FT IR, 1H NMR, 13C NMR, 2D NMR and EI MS as well as comparison with reported data. The antimicrobial activity of pet-ether, ethyl acetate, ethanol and water extracts from flowers, leaves and bark of P. pterocarpum was screened against the six microorganisms Bacillus subtilis, Bacillus pumiIus, Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans and Escherichia coli using the agar well diffusion method. All the crude extracts exhibited inhibition zone diameters ranging between 12mm and 20mm. The watery and ethanol extracts were free from acute toxicity on albino mice (20- 30g). In the antioxidant DPPH assay, the IC50 values of ethanol and watery extracts of all parts ranged between 0.65 and 2.44 μg/mL, having a pronounced antioxidant property. In the resazurin microplate assay, ethanol extract of flowers, leaves and bark exhibited 15, 62 and 72% cell death rates on colon cancer stem cells and 8, 27 and 23% on human lung fibroblast with a 1.5 mg/mL dose.
Nwet Nwet Win
Myint Myint Htwe
Ni Ni Than
- Sustainability in Myanmar. Southeast Asian Modernities